Theca cells and the regulation of ovarian androgen production
نویسندگان
چکیده
منابع مشابه
P-25: Characterization of Sheep Ovarian Multipotent Theca Stem Cells
Background Theca cells play important roles during folliculogenesis. They synthesize androgens, provide crosstalk with granulosa cells and oocytes during development, and provide structural support of the growing follicle to produce a mature and fertilizable oocyte. In children patients who are going to be ovariectomy, follicogenesis is at early stage and thus the follicles need to be mature in...
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During ovarian follicle growth, precise regulation of the onset of androgen production by ovarian theca-interstitial cells (TIC) is necessary for maintaining follicle viability. Thus, temporary suppression of TIC androgen production in preantral follicles is the key to promoting follicle development. Evidence indicates that this process is coordinated via intraovarian growth factors. Hepatocyte...
متن کاملHeterogeneity of Ovarian Theca and Interstitial Gland Cells in Mice
It has been established that two developmentally and functionally distinct cell types emerge within the mammalian testis and adrenal gland throughout life. Fetal and adult types of steroidogenic cells (i.e., testicular Leydig cells and adrenocortical cells) develop in the prenatal and postnatal period, respectively. Although the ovary synthesizes steroids postnatally, the presence of fetal-type...
متن کاملOestradiol feedback stimulation of androgen biosynthesis by human theca cells.
This study analysed the effect of oestradiol on basal and LH-stimulated production of androstenedione and progesterone by human theca cells in monolayer culture. Incubations were carried out for either 2 days (seven experiments) or 4 days (four experiments), in the presence or absence of luteinizing hormone (LH), oestradiol (10(-9)-10(-6) M) or inhibin. Medium collected at 48 and 96 h was store...
متن کاملKit ligand actions on ovarian stromal cells: effects on theca cell recruitment and steroid production.
Factors that control recruitment of theca cells from ovarian stromal-interstitial cells are important for early follicle development in the ovary. During recruitment, theca cells organize into distinct layers around early developing follicles and establish essential cell-cell interactions with granulosa cells. Recruitment of theca cells from ovarian stromal stem cells is proposed to involve cel...
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ژورنال
عنوان ژورنال: Bioscientifica Proceedings
سال: 2019
ISSN: 2515-0227
DOI: 10.1530/biosciprocs.8.021